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improve content uniformity by milling

Improving the content uniformity of a low-dose tablet

The results from the confirmation trial proved that the new roller compaction and milling conditions reduced the potential for segregation by minimizing the granulation potency variability as a function of particle size as expressed by sieve cut potency % RSD, and thus improved content uniformity of stratified tablet samples.

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Ich Improve Content Uniformity By Milling

Ich Improve Content Uniformity By Milling. Milling Equipment: ich improve content uniformity by milling A class of machinery and equipment that can be used to meet the production requirements of coarse grinding, fine grinding and super fine grinding in the field of industrial grinding.The finished product can be controlled freely from 0 to 3000 mesh.

Improve Particle Uniformity with Roller Mill Technology

In contrast, roller mills typically create 50 to 75% fewer fines and improve particle uniformity by 50 to 100%. Since hammer mills and other attrition milling methods involve multiple impacts, they typically require relatively higher energy use. Energy savings is a primary reason to choose roller mills over traditional particle-reduction methods.

Improving the Content Uniformity of a Low-Dose Tablet

The purpose of this investigation was to minimize the segregation potential by improving content uniformity across the granule particle size distribution, thereby improving content uniformity in

Improve the field emission uniformity of carbon nanotubes

Jan 15, 2007· After ball-milling process, the h/r of CNTs becomes lower, i.e. h/r is about 10 for 0.5–1 h milling, and less than 10 for more than 1 h milling. The relative uniformity and higher enhancement factor of the CNTs treated for 0.5–1 h make field emission property more

Cited by: 8

Effect of drug particle size on content uniformity of low

Aug 26, 1997· However, this analysis is useful in determining whether drug particle size or mixing is responsible for poor content uniformity. It should be noted that reduc- ing particle size in an attempt to improve content uniformity may not work if at the same time, it increases the tendency of the drug particles to aggregate. Y.

WO2008091957A2 Pharmaceutical compositions containing

The invention provides pharmaceutical compositions containing ibuprofen in combination with a second pharmaceutically active ingredient, such as famotidine. The invention also provides unit dosage forms containing ibuprofen and famotidine. Such unit dosage forms have significantly improved content uniformity.

Using Dry Blend For Low-Dose Uniformity Contract Pharma

May 02, 2014· Different manufacturing methods can result in different content uniformity issues. In this article, we compare results we found using geometric dilution, wet granulation and a dry blend process to manufacture a low-dose, immediate-release solid dosage form. We used content uniformity, as defined by USP <905>, to determine dose uniformity.

US8703187B2 Vitamin D content uniformity in

US8703187B2 US12/148,987 US14898708A US8703187B2 US 8703187 B2 US8703187 B2 US 8703187B2 US 14898708 A US14898708 A US 14898708A US 8703187 B2 US8703187 B2 US 8703187B2 Authority US United States Prior art keywords calcium carbonate vitamin mixture blending granulation Prior art date 2007-04-25 Legal status (The legal status is an assumption and is not a

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The Granulation Process 101 Techceuticals

improve flow and compression characteristics,reduce segregation, improve content uniformity,and eliminate excessive amounts of fine particles.The results will be improved yields,reduced tablet defects,increased productivity,and reduced down time.The objective of the process is to combine ingredients to produce a quality tablet. IMAGE 100

Effect of drug particle size on content uniformity of low

Aug 26, 1997· However, this analysis is useful in determining whether drug particle size or mixing is responsible for poor content uniformity. It should be noted that reduc- ing particle size in an attempt to improve content uniformity may not work if at the same time, it increases the tendency of the drug particles to aggregate. Y.

Improve the field emission uniformity of carbon nanotubes

Jan 15, 2007· After ball-milling process, the h/r of CNTs becomes lower, i.e. h/r is about 10 for 0.5–1 h milling, and less than 10 for more than 1 h milling. The relative uniformity and higher enhancement factor of the CNTs treated for 0.5–1 h make field emission property more

Rasagiline formulations of improved content uniformity

Feb 22, 2006· Milling, as well as other methods, can be used to alter the particle size distribution (hereinafter “PSD”) of R(+)PAI in order to provide greater uniformity of content of the drug product. The object of the present invention is to provide content uniformity of drug products comprising R(+)PAI, comprising milling R(+) particles to reduce

Using Dry Blend For Low-Dose Uniformity Contract Pharma

May 02, 2014· Different manufacturing methods can result in different content uniformity issues. In this article, we compare results we found using geometric dilution, wet granulation and a dry blend process to manufacture a low-dose, immediate-release solid dosage form. We used content uniformity, as defined by USP <905>, to determine dose uniformity.

Improve the field emission uniformity of carbon nanotubes

Carbon nanotubes (CNTs) deposited by chemical vapor deposition (CVD) were treated by ball milling. The morphologies and field emission properties of the treated CNTs depending on milling time were studied. The emission turn-on field is increased, and the field emission current density is reduced, when the milling time increased from 0.5 to 3 h. The as-deposited long CNTs were cut to short CNTs

Improving the Content Uniformity of a Low-Dose Tablet

The results from the confirmation trial proved that the new roller compaction and milling conditions reduced the potential for segregation by minimizing the granulation potency variability as a function of particle size as expressed by sieve cut potency % RSD, and thus improved content uniformity of stratified tablet samples.

US8703187B2 Vitamin D content uniformity in

US8703187B2 US12/148,987 US14898708A US8703187B2 US 8703187 B2 US8703187 B2 US 8703187B2 US 14898708 A US14898708 A US 14898708A US 8703187 B2 US8703187 B2 US 8703187B2 Authority US United States Prior art keywords calcium carbonate vitamin mixture blending granulation Prior art date 2007-04-25 Legal status (The legal status is an assumption and is not a

[PDF]

The Granulation Process 101 Techceuticals

improve flow and compression characteristics,reduce segregation, improve content uniformity,and eliminate excessive amounts of fine particles.The results will be improved yields,reduced tablet defects,increased productivity,and reduced down time.The objective of the process is to combine ingredients to produce a quality tablet. IMAGE 100

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Effect of roll-compaction and milling conditions on

into granules. Regarding the milling step, many variables, such as mill type, mill design, screen size, speed and mode of oscillation, have a significant influence on the quality of granules. The most important resultant property of the milling step is the particle size distribution. In order to improve the efficiency of dry granulation

(PDF) Concepts and Techniques of Pharmaceutical Powder

The content uniformity criterion was achieved with an acceptance value <20. In vitro dissolution, Q1 and Q2 were 100% and 98.8%, respectively, in 30 min and followed first-order kinetics.

Analyzing Content Uniformity | Pharmaceutical Technology

Feb 02, 2018· Sampling strategies. Guidance such as United States Pharmacopeia (USP) <905> (1), European Pharmocopoeia (PhEur) 2.9.40 (2), and other pharmacopeia chapters have set out the requirements for UDU by content uniformity testing. Generally, only 10 tablets from a batch have to be tested, Andrews notes. “These samples are assayed individually and a calculation using the individual

Resolving Issues of Content Uniformity and Low

The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and

Ribbon density and milling parameters that determine fines

A challenge in the dry granulation (DG) process is the generation of an excessive amount of fines during milling, which can cause problems in die filling due to poor flowability and content uniformity of tablets.

Improve Particle Uniformity with Roller Mill Technology

Apr 23, 2008· In contrast, roller mills typically create 50 to 75% fewer fines and improve particle uniformity by 50 to 100%. Since hammer mills and other attrition milling methods involve multiple impacts, they typically require relatively higher energy use. Energy savings is a primary reason to choose roller mills over traditional particle-reduction methods.

Resolving Issues of Content Uniformity and Low

The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and

Improve the field emission uniformity of carbon nanotubes

Carbon nanotubes (CNTs) deposited by chemical vapor deposition (CVD) were treated by ball milling. The morphologies and field emission properties of the treated CNTs depending on milling time were studied. The emission turn-on field is increased, and the field emission current density is reduced, when the milling time increased from 0.5 to 3 h.

(16b) Novel Technologies to Improve the Bioavailability

Apr 23, 2018· (16b) Novel Technologies to Improve the Bioavailability, Content Uniformity and Manufacturing of Pharmaceuticals. Conference: World These unit operations can include crystallization and various milling steps. we will present results showing that this process can deliver powder with high blend uniformity and tablets/capsules with high

Cone Mill | Conical Milling for size reduction | Quadro

Cone milling is one of the most common methods of milling in the pharmaceutical, food, chemical and associated industries. They are typically used for size reduction and deagglomeration or delumping of powders and granules.. Generally used for reducing material to a particle size as low as 180µm (80 mesh) they produce less dust and heat than alternative forms of milling.

Blend Uniformity in Pharmaceutical Solid Dosage Forms

But the industry standard for content uniformity is 90-110%. Blend sampling errors play an important role in formulation of dosage form where homogeneity is must. In a well controlled manufacturing processes, a firm may be able to justify using a batch or lot representative Assay and Assay Range approach to justify the release of final Powder

Analyzing Content Uniformity | Pharmaceutical Technology

Feb 02, 2018· Sampling strategies. Guidance such as United States Pharmacopeia (USP) <905> (1), European Pharmocopoeia (PhEur) 2.9.40 (2), and other pharmacopeia chapters have set out the requirements for UDU by content uniformity testing. Generally, only 10 tablets from a batch have to be tested, Andrews notes. “These samples are assayed individually and a calculation using the individual

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Effect of roll-compaction and milling conditions on

into granules. Regarding the milling step, many variables, such as mill type, mill design, screen size, speed and mode of oscillation, have a significant influence on the quality of granules. The most important resultant property of the milling step is the particle size distribution. In order to improve the efficiency of dry granulation

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AlN Film Stress and Uniformity for BAW filters on 200mm

precisely control center-to-edge thickness uniformity. Wafer rotation is also used to improve both thickness uniformity and stress variation across wafer. Figure 7 below shows a typical configurations (magnetic and electrical) used for the 200mm wafers. Figure 6.

(PDF) Concepts and Techniques of Pharmaceutical Powder

The content uniformity criterion was achieved with an acceptance value <20. In vitro dissolution, Q1 and Q2 were 100% and 98.8%, respectively, in 30 min and followed first-order kinetics.

Blend Uniformity and Content Uniformity (BUCU) FAQs | ISPE

Nov 01, 2017· Testing may also be reduced to after a due diligent effort to improve the process still results in high but consistent (and acceptable) standard deviations for the blend and/or dosage unit data, indicating that is the best uniformity that the process can achieve. Reference: Bergum J., et. al., Current Events in Blend and Content Uniformity

Manufacture of Pharmaceutical Tablets Pharmapproach

The design and manufacture of pharmaceutical tablets is a complex multi-stage process whereby formulation scientists ensure that the correct amount of drug substance in the right form is delivered at the appropriate time, at the proper rate and in the desired location with its chemical integrity protected to that point. Most drug substances do not possess the required properties which give

Energy efficiency improving and pellet uniformity control

Sep 05, 2011· Energy efficiency improving and pellet uniformity control in the extrusion of aquafeed one of the development trends in aquafeed milling is that the extruder is taking the place of pellet mill and becoming the most popular and most efficient milling machine because of its flexible production adaptability, high product quality and high

Chapter 18. Feed Milling Processes

The mill consists of a rotating shaft with four attached parallel knives and a screen occupying one fourth of the 360 degree rotation. The mill is best used to crack whole grains with a minimum of "fines". It is not used as a final process for reducing the size of ingredients used in fish feeds. 2.5 Screening

Particle Size Specifications for Solid Oral Dosage Forms

May 01, 2010· Due to the small size of pellets, measurement of weight gain is not meaningful for control of coating uniformity. Instead, for each coating stage, coating uniformity should be assessed by assay and content uniformity of API for the unit-dose samples collected by an appropriate sampling plan at multiple locations.